A Step Toward Making Painkillers Without Poppies Bioengineering: Modified...
Using thebaine as the starting material, the same set of enzymes can catalyze reactions in different pathways leading to either morphine or neomorphine. With the addition of bacterial enzymes, they...
View ArticlePlerixafor..............an immunostimulant used to mobilize hematopoietic...
Plerixaforcas 110078-46-1CXCR4 chemokine antagonistStem cell mobilization [CXCR4 receptor antagonist]A bicyclam derivate, highly potent & selective inhibitor of HIV-1 & HIV-2.Bone marrow...
View ArticleInfinity and AbbVie partner to develop and commercialise duvelisib for cancer
DuvelisibInfinity and AbbVie partner to develop and commercialise duvelisib for cancerINK 1197; IPI 145; 8-Chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinoneMolecular...
View ArticleTecadenoson…………Atrial Fibrillation
TecadenosonCAS : 204512-90-3N-[(3R)-Tetrahydro-3-furanyl]adenosine(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diolN-(3-Tetrahydrofuranyl)-6-aminopurine...
View ArticleHighly regioselective lithiation of pyridines bearing an oxetane unit by...
Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium, G. Rouquet, D.C. Blakemore, S.V. Ley,Chem. Comm., 2014, 50,...
View ArticleDasotraline, 1R,4S Transnorsertraline, SEP-225289………For treatment of...
Dasotraline, SEP-225289, DSP-225289 1R,4S TransnorsertralineGeneric Name:DasotralineSynonym: SEP-225289Chemical...
View ArticleFDA Approves Trulicity (dulaglutide) for Type 2 Diabetes
FDA Approves Trulicity (dulaglutide) for Type 2 DiabetesDULAGLUTIDEPRONUNCIATION doo” la gloo’ tideTHERAPEUTIC CLAIM Treatment of type II diabetesCHEMICAL NAMES1. 7-37-Glucagon-like peptide I...
View ArticleTalaglumetad hydrochloride
Talaglumetad hydrochlorideFORMULAC11H16N2O5. HClEXACT MASS292.0826MOL WEIGHT292.7161CAS: 441765-97-5441765-98-6 (free base)IUPAC Name:...
View ArticleA smarter way to find new drugs
End to end solutions Big Data push to research In Green / shutterstock.comThe pharma sector needs to embrace emerging technologies like Big Data analytics and cloud computingWhat is the secret sauce of...
View ArticleARTESUNATE
ARTESUNATECAS 88495-63-0Butanedioic acid mono[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] esterAdditional Names: artesunic acid;...
View ArticleAptamers For Small Molecules
A new method selects aptamers that bind a complex of a synthetic receptor (blue) and a small molecule (red). Credit: Milan Stojanovic Aptamers For Small MoleculesBiosensors: Strategy for designing...
View ArticlePalladium-heterogenized porous polyimide materials as effective and...
Green Chem., 2015, Advance ArticleDOI: 10.1039/C4GC01326C, PaperE. Rangel Rangel, E. M. Maya, F. Sanchez, J. G. de la Campa, M. IglesiasFunctionalized porous polyimides were used as supports for...
View ArticleQbD essential as tablet makers shift to continuous production, says Freeman
QbD essential as tablet makers shift to continuous production, says FreemanBy Dan Stanton+, 09-Oct-2014Drugmakers will “inevitably” shift from batch to continuous production of tablets and, according...
View ArticleHikma: API facility bolsters our oncology pipeline
Hikma: API facility bolsters our oncology pipelineBy Dan Stanton+, 23-Sep-2014Hikma has opened a new API facility in Jordan to support its oncology...
View ArticleLonza goes with the Flow Chemistry with latest API platform
Lonza goes with the Flow Chemistry with latest API platformBy Fiona Barry +, 07-Oct-2014Lonza has launched an API-making platform that uses chemical microreaction technology for continuous...
View ArticleContinuous Flow Total Synthesis of Rufinamide
Small molecules bearing 1,2,3-triazole functionalities are important intermediates and pharmaceuticals. Common methods to access the triazole moiety generally require the generation and isolation of...
View ArticleApplication of Continuous Flow Micromixing Reactor Technology for Synthesis...
Synthesis of pharmaceutically active compounds by employing continuous flow micromixing reactor technology is an interesting research area. In this article we describe the synthesis of benzimidazole...
View ArticleAntimalarial flow synthesis closer to commercialisation
The divergent, multi-step continuous process includes continuous in-line purificationScientists in Germany have demonstrated the large scale and inexpensive production of a range of antimalarial drugs,...
View ArticleA flow process using microreactors for the preparation of a quinolone...
QuinolonesThe quinolone derivative shown below is a potent 5HT1B antagonist developed by AstraZeneca. The continuous flow synthesis (the final steps shown below) of this pharmaceutical agent was...
View ArticleThe Most Popular Drug in America Is an Antipsychotic and No One Really Knows...
100 tablets of Seroquel cost as much as $2,000, Zyprexa, $1,680 and Abilify $1,644.The Most Popular Drug in America Is an Antipsychotic and No One Really Knows How It...
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