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A Step Toward Making Painkillers Without Poppies Bioengineering: Modified...

  Using thebaine as the starting material, the same set of enzymes can catalyze reactions in different pathways leading to either morphine or neomorphine. With the addition of bacterial enzymes, they...

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Plerixafor..............an immunostimulant used to mobilize hematopoietic...

Plerixaforcas 110078-46-1CXCR4 chemokine antagonistStem cell mobilization [CXCR4 receptor antagonist]A bicyclam derivate, highly potent & selective inhibitor of HIV-1 & HIV-2.Bone marrow...

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Infinity and AbbVie partner to develop and commercialise duvelisib for cancer

DuvelisibInfinity and AbbVie partner to develop and commercialise duvelisib for cancerINK 1197; IPI 145; 8-Chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinoneMolecular...

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Tecadenoson…………Atrial Fibrillation

TecadenosonCAS : 204512-90-3N-[(3R)-Tetrahydro-3-furanyl]adenosine(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diolN-(3-Tetrahydrofuranyl)-6-aminopurine...

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Highly regioselective lithiation of pyridines bearing an oxetane unit by...

Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium, G. Rouquet, D.C. Blakemore, S.V. Ley,Chem. Comm., 2014, 50,...

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Dasotraline, 1R,4S Transnorsertraline, SEP-225289………For treatment of...

Dasotraline,  SEP-225289, DSP-225289  1R,4S TransnorsertralineGeneric Name:DasotralineSynonym: SEP-225289Chemical...

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FDA Approves Trulicity (dulaglutide) for Type 2 Diabetes

FDA Approves Trulicity (dulaglutide) for Type 2 DiabetesDULAGLUTIDEPRONUNCIATION doo” la gloo’ tideTHERAPEUTIC CLAIM Treatment of type II diabetesCHEMICAL NAMES1. 7-37-Glucagon-like peptide I...

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Talaglumetad hydrochloride

Talaglumetad hydrochlorideFORMULAC11H16N2O5. HClEXACT MASS292.0826MOL WEIGHT292.7161CAS: 441765-97-5441765-98-6 (free base)IUPAC Name:...

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A smarter way to find new drugs

End to end solutions Big Data push to research In Green / shutterstock.comThe pharma sector needs to embrace emerging technologies like Big Data analytics and cloud computingWhat is the secret sauce of...

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ARTESUNATE

ARTESUNATECAS 88495-63-0Butanedioic acid mono[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] esterAdditional Names: artesunic acid;...

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Aptamers For Small Molecules

  A new method selects aptamers that bind a complex of a synthetic receptor (blue) and a small molecule (red). Credit: Milan Stojanovic Aptamers For Small MoleculesBiosensors: Strategy for designing...

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Palladium-heterogenized porous polyimide materials as effective and...

Green Chem., 2015, Advance ArticleDOI: 10.1039/C4GC01326C, PaperE. Rangel Rangel, E. M. Maya, F. Sanchez, J. G. de la Campa, M. IglesiasFunctionalized porous polyimides were used as supports for...

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QbD essential as tablet makers shift to continuous production, says Freeman

QbD essential as tablet makers shift to continuous production, says FreemanBy Dan Stanton+, 09-Oct-2014Drugmakers will “inevitably” shift from batch to continuous production of tablets and, according...

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Hikma: API facility bolsters our oncology pipeline

Hikma: API facility bolsters our oncology pipelineBy Dan Stanton+, 23-Sep-2014Hikma has opened a new API facility in Jordan to support its oncology...

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Lonza goes with the Flow Chemistry with latest API platform

Lonza goes with the Flow Chemistry with latest API platformBy Fiona Barry +, 07-Oct-2014Lonza has launched an API-making platform that uses chemical microreaction technology for continuous...

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Continuous Flow Total Synthesis of Rufinamide

Small molecules bearing 1,2,3-triazole functionalities are important intermediates and pharmaceuticals. Common methods to access the triazole moiety generally require the generation and isolation of...

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Application of Continuous Flow Micromixing Reactor Technology for Synthesis...

Synthesis of pharmaceutically active compounds by employing continuous flow micromixing reactor technology is an interesting research area. In this article we describe the synthesis of benzimidazole...

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Antimalarial flow synthesis closer to commercialisation

The divergent, multi-step continuous process includes continuous in-line purificationScientists in Germany have demonstrated the large scale and inexpensive production of a range of antimalarial drugs,...

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A flow process using microreactors for the preparation of a quinolone...

QuinolonesThe quinolone derivative shown below is a potent 5HT1B antagonist developed by AstraZeneca. The continuous flow synthesis (the final steps shown below) of this pharmaceutical agent was...

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The Most Popular Drug in America Is an Antipsychotic and No One Really Knows...

100 tablets of Seroquel cost as much as $2,000, Zyprexa, $1,680 and Abilify $1,644.The Most Popular Drug in America Is an Antipsychotic and No One Really Knows How It...

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